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University of Central Oklahoma

Classes Taught

Biochemistry I ( CHEM 3403)

Biochemistry II (CHEM 4103 and 5103)

Experimental Biochemistry (CHEM 3442)

General Chemistry I and II and Introduction to Chemistry

Research, Published Work, and Scholarly Activities

1. Chooback, L.,Thomas L.M., Woellmer, K.L., Karsten, B.A. (2023) Crystal structure of Escherichia coli dihydrodipicolinate synthase in complex with 3-iodopropionic acid. Protein Data Bank ID 8T2K

2. Chooback, L., Thomas, L.M., Blythe, N., Karsten, W.E (2022) Kinetic and structural studies of the reaction of Escherichia coli dihydrodipicolinate synthase with (S)-2-bromopropionate. Acta Cryst. D78, 

3. Karsten, W.E., Thomas, L.M., Karsten, Fleming, C.D., Seabourn, P., Bruxvoort, C., Chooback, L. (2021) Kinetic and structural studies of the slow-binding inhibition of dihydrodipicolinate synthase from Escherichia coli by 2, 4-oxo-pentanoic acid. Archives of Biochemistry and Biophysics: 702,108819, PMID: 33639104, PMCID: PMC8592399, DOI: 10.1016/

4.  Chooback, L., Thomas, L.M., Karsten, W.E., Fleming, C.D., Seabourn, P. (2019) Structural studies of Escherichia coli dihydrodipicilinate synthase and propionate covalently bound to K161. Protein Data Bank, ID 6NVA

5. Karsten, W.E., Nimo, S., Liu, J., Chooback, L. (2018) Identification of 2, 3-dihydrodipicolinate as the product of the dihydrodipicolinate synthase from Escherichia coli, Archives of Biochemistry and Biophysics: 1;653:50-62, PMID: 29944868

6. Chooback, L., Thomas, L.M., Karsten, W.E., Fleming, C.D., Seabourn, P. (2017) Kinetic, Spectral and Structural Characterization of the Slow Binding Inhibitor Acetopyruvate and allosteric inhibitor lysine with Dihydrodicpicolinate Synthase from Escherichia coliProtein Data Bank, ID 5T26

7. Chooback, L., Thomas, L.M., Karsten, W.E., Fleming, C.D., Seabourn, P. (2017) Kinetic, Spectral and Structural Characterization of the Slow Binding Inhibitor Acetopyruvate with Dihydrodicpicolinate Synthase from Escherichia coliProtein Data Bank, ID 5T25

8. Daghutry, Y., Evans, R., and Chooback, L. (2016) Cloning, Expression, and Purification of Histidine-Tagged Escherichia coli Dihydrodipicolinate Reductase. PLOS ONE, PMID: 26815040

9. Chen, Y., Anwuli, A., Chooback, L. (2014) Potato Catalase Enzyme Kinetics: A Simple Experimental Method.  Journal of Undergraduate Research: 1, 32-35

10. Karsten, W.E., Reyes, R., Bobyk, K.D., Cook, P.F., and Chooback, L. (2011) Kinetics and Spectral Characterization of an Aromatic Aminotransferasee from Sacchromyces cerevisiaeArchives of biochemistry and biophysics 516(1): 67-74. PMID: 21982920

11. Zahran, Z., Chooback, L., Copeland, D. and Richter-Addo, G. (2008) Molecular Structures of Manganese Reconstituted Myoglobin Complexed with Nitrite, Azide, Methanol and Nitric Oxide.  Journal of Inorganic Biochemistry 102(2): 216-233, PMID: 17905436

12. Richter-Addo, G.B., Zahran, Z.N., Chooback, L., Copeland, D.M., West, A.H. (2007) Crystal structure of horse heart met manganese myoglobin.  Protein Data Bank, PDBe ID 2050, PDB DOI: 10.2210/pdb2O58/pdb

13. Chooback, L. and West, A.H. (2003) Co-crystallization of yeast phosphorelay protein YPD1 with SLN1 response-regulator domain and preliminary X-ray diffraction analysis.  Acta Crystallogr D Biol Crystallogr 59 (Pt5): 927-929, PMID: 12777814

14. Jeffrey M Weinberg, Leonard Kristal, Lillian Chooback, Paul J Honig, E Michael Kramer, Stuart R Lessin (2002) The clonal nature of pityriasis lichenoides.  Arch Dermatol, 138(8):1063-7.  PMID: 12164744, DOI: 10.1001/archderm.138.8.1063

15. Liu, T., Mirschberger, C., Chooback, L., Arana, Q., Sacco, Z.D., MacWilliams, H. and Clark, M. (2002) Altered expression of the 100 kDa subunit of the Dictyostelium vasculor proton pump impairs enzyme assembly, endocytic function and cytosolic pH regulation.  J. Cell Science 115: 1907-1918, PMID: 11956322

16. Zhang, L., Chooback, L. and Cook, P.F. (1999) Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalysed reaction.  Biochemistry 38(35): 11231-11238, PMID: 10471272

17. Karsten, W.E., Chooback, L., Liu, D., Hawang, C-C, Lynch, C. and Cook, P.F. (1998) Mapping the active Site Topology of the NAD-Malic Enzyme via Site-Directed Mutagenesis.  Biochemistry 38(32): 10527-10532, PMID: 10441149

18. Karsten, W.E., Chooback, L. and Cook, P.F. (1998) Glutamate 190 is a general acid catalyst in the 6-phosphogluconate dehydrogenase catalyzed reaction.  Biochemistry 37(45): 15691-15697, PMID: 9843373

19. Chooback, L., Price, N.E., Karsten, W.E., Nelson, J., Sundstrom, P.R., and Cook, P.F. (1998) Cloning, Expression, Purification, and Characterization of the 6-Phosphogluconate Dehydrogenase from Sheep Liver.  Protein Expression and Purification 13: 251-258, PMID: 9675070

20. Rebeil, R., Chooback, L., Pedraza-Reyes, M., Kinsland, C., Begley, T.P. and Nicholson, W.L. (1998) Spore photoproduct lyase from Bacillus subtilis spore is a novel iron-sulfur DNA repair enzyme which shares features with protein such as class III anaerobic ribonucleotide reductases and pyruvate-formate lyases.  Journal of Bacteriology 180(18): 4879-4885, PMID: 9733691

21. Li, G., Chooback, L., Wolfe, J.T., Rook, A.H., Felix, C.A., Lessin, S.R. and Salhany, K.E. (1998) Overexpression of p53 protein in cutaneous T cell lymphoma: relationship to large cell transformation and disease progression.  Journal of Investigative Dermatology 110(5): 576-570, PMID: 9579543

22. Chooback, L., Karsten, W.E., Kulkarni, G., Nalabolu, S.R., Harris, B.G., and Cook, P.F. (1997) Expression, Purification, and Characterization of the Recombinant NAD-Malic Enzyme from Ascaris suumProtein Expression and Purification 10: 51-54, PMID: 9179290 DOI: 10.1006/prep.1996.0705

23. Nicholson, W.L., Chooback, L., Fajardo-Cavazos, P., Nicholson, W.L. (1997) Analysis of spore photoproduct lyase operon (splAB) function using targeted deletion-insertion mutations spanning the Bacillus subtilis operons ptsHI and splAB.  Mol. Gen. Genet. 255(6):587-94, PMID: 9323362

24. Finn, D.T., Jaworsky, C., Chooback, L., Jensen, P.J., Lessin, S.R. (1996) Correlation between clonotypic T-cell receptor beta chain variable region (TCR-Vβ) gene expression and aberrant T-cell antigen expression in cutaneous T-cell lymphoma.  Journal of cutaneous pathology,23(4):306-311.


25. Resnik, K.S., Kantor, G.R., Lessin, S.R., Kadin, M.E, Chooback, L., Cooper, H.S.,  Vonderheid, E.C., (1995) Mycosis Fungoides Palmaris et Plantaris.  Arch Dermatol. 1995;131(9):1052-1056. doi:10.1001/archderm.1995.01690210082013


Protein chemistry and enzyme kinetics, Structural Biology, Molecular Biology, Microbiology, Drug design

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